10/8/2019 Continuous Flow Synthesis Fluoxetine
The concepts article describes enabling techniques (solid‐phase assisted synthesis, new reactor design, microwave irradiation and new solvents) in organic chemistry and emphasizes the combination of several of them for creating new synthetic technology platforms. Particular focus is put on the combination of immobilized catalysts as well as biocatalysts with continuous flow processes. In this context, the PASSflow continuous flow technique fulfils both chemical as well as chemical engineering requirements. It combines reactor design with optimized, monolithic solid phases as well as reversible immobilization techniques for performing small as well as large scale synthesis with heterogenized catalysts under continuous flow conditions.
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Flow reactors, however, in which reactions occur in continuously flowing fluids, are more efficient tools, especially for large-scale chemical synthesis. Compared with conventional batch production, continuous-flow synthesis features excellent heat and mass transfer rates, safe operation under high pressures and temperatures, and precise control of conditions. We studied the fluorination of cytosine using a continuous flow reactor system where greater fluorination reaction control may be possible. Flucytosine 1: related pharmaceuticals and synthesis. Synthesis of Flucytosine cytosine 1 fluorine conversion 2:3 yield 2 Batch Conditions 1.0 equiv 1.75 equiv 99% 44:56 38%.
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